COVER LETTER FINAL VERSION

Dr Edmund Sonuga-Barke
Editor in chief
Journal of child Psychology and Psychiatry

Dear Dr Sonuga-Barke

We are submitting the manuscript "Association between maternal care and glucocorticoid receptor gene methylation in human leucocytes". This is the one of the first evidence in humans of epigenetic mechanism related to behavior in children. It shows the interaction between psychological issues as maternal care and child abuse, with their biological and epigenetical roots, specifically with methylation of glucocorticoid receptor gene. This work, also facilitates a more scientifically based study of human behavior.

This study was developed with the parents consent and was aproved by the University of Chile Ethical Comitee. The article has not be submitted to other journal and we do not have conflict of interest

The article is authored by Raúl Ventura-Juncá MD. MSc., Luisa Herrera Phd. and Yenny Fiedler Phd. in a collaborative work of genetics and neuroscience laboratories.

Sincerely,

Raúl Ventura-Juncá, MD. MSc.